Special Feature. Surgical stress and immune response. Tissue injury by free radicals after surgical stress.

Free radicals and tissue injury -

Surgical stress and the small intestine: role of oxygen free radicals.

BACKGROUND Any surgical procedure can be associated with altered intestinal function. The mechanism involved in these changes at the cellular level during surgical stress has not been worked out. This study looked at the biochemical and functional alterations, along with ultrastructural changes, in the intestine during surgical stress in a simple rat model. METHODS Surgical stress was induced...

Surgical stress-induced alterations in retinoid metabolism in the small intestine: role of oxygen free radicals.

Oxidative stress in the small intestine can result in altered cell proliferation, migration, and differentiation of villus-crypt cells. Retinoid metabolism is recognized as an important mediator of cellular differentiation in the intestine. This study examined the effect of oxidative stress in retinoid metabolism in a surgical stress model. Surgical stress was performed by handling the intestin...

Exercise, free radicals and oxidative stress.

This article reviews the role of free radicals in causing oxidative stress during exercise. High intensity exercise induces oxidative stress and although there is no evidence that this affects sporting performance in the short term, it may have longer term health consequences. The mechanisms of exercise-induced oxidative stress are not well understood. Mitochondria are sometimes considered to b...

Sever Gastrointestinal Caustic Injury and Surgical Treatment

Approximately 20% of caustic ingestions result in some degree of esophageal injury. Alkaline materials are the most frequent corrosive materials ingested.     The physical form and PH of ingested materials play a critical role in the site and type of gastrointestinal injury (PH > 12 or PH < 1.5, crystalline drain cleaners). Unlike Alkaline solutions, strong acids are bitter, burn on contact and...